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شانتی رنجن بھٹاچاریہ

شانتی رنجن بھٹا چاریہ
جناب شانتی رنجن بھٹا چاریہ کے انتقال سے اردو زبان اپنے ایک مخلص خادم اور زبردست شیدائی سے محروم ہوگئی وہ موجودہ بنگلہ دیش کے ضلع جیسور میں پیدا ہوئے تھے اور ان کی تعلیم حیدرآباد میں ہوئی تھی مگر کلکتہ ان کی سرگرمیوں کا مرکز رہا وہ عرصہ تک مغربی بنگال کے محکمۂ اطلاعات سے اور کچھ عرصہ تک مرکزی وزارت اطلاعات و نشریات سے بھی وابستہ رہے، جناب شانتی رنجن بنگالی اور اردو دونوں کے ماہر اور اردو کے ممتاز مصنف تھے۔ انہوں نے بنگلہ ادب کی تاریخ کے علاوہ بنگالی ناولوں کے ترجمے سے بھی اردو کے سرمایہ میں اضافہ کیا، وہ انجمن ترقی اردو کی مجلس عام اور اردو یونیورسٹی کمیٹی کے رکن بھی تھے، بنگال میں اردو کے فروغ اور مغربی بنگال اردو اکیڈمی کے قیام میں ان کا بڑا دخل تھا، ان کی ادبی خدمات کے اعتراف میں میر اکیڈمی لکھنؤ اور ساہتیہ اکیڈمی دہلی سے انہیں ایوارڈ بھی ملے، شانتی رنجن جی ہماری مشترکہ تہذیب کے عاشق اور صحیح معنوں میں سیکولر تھے، ہر شخص سے خوش اخلاقی اور گرم جوشی سے ملتے، راقم سے بھی دوبار ملاقات ہوئی تو اپنے خلوص و محبت کا نقش دل پر بیٹھا گئے۔ (ضیاء الدین اصلاحی۔ اکتوبر ۱۹۹۳ء)

 

سیرت رسول عربی ﷺ(از نور بخش توکلی)کے منہج و اسلوب کا تجزیاتی مطالعہ

The topic of ‘Sacred role (Seerat)’ with the affinity of the Rasool (saw) having significance, status and vast acceptance is undoubtedly beyond expression. If we make analysis of a religious literature, we find most of its part consisting on such topics that are directly affiliated with the silent features of the personality of the Rasool (saw). In storehouse of knowledge and architecture of the world ‘Art of Sacred role’ has attained its prominent supremacy. The beginning of this art was based on the details of Ghazwat in Islam but with the passage of time, it was enlarged in such a way that a great piece of literary work on ‘Sacred role’ has been pin pointed in sub-continent. Many literate of persona put forth their pens on this topic out of whom Noor Bakhsh Tawakli is also the most famous name who wrote a with title of “Seerat Rasool-e-Arabi” on the personality of Rasool. The expression of the affection and following of the Rasool (saw) by Noor Bakhsh Tawakli is expressed by the leaves of this book. He is best known for his popular for this book which has its own status in this field. He wrote the book in the era during which the western civilization had strangled the youth of that time. Materialism was in its climax. A great piece of strife was being made to disintegrate the true bond of affection and following of the Rasool (saw) but the profundity of learning, recognition of knowledge, strict eye on the present condition of that time and the salient factors of love of the Rasool (saw) were quite dominant in this book. The leaves of which were enriched with the florescence of love and affection of Rasool(saw).  

Development of Nano-Scaled Silibinin and Berberine Formulations to Enhance Their Bioavailability for Hepatoprotective and Anticancer Activities

The oral route of drug administration is usually preferred among the other routes due to ease of administration. Problems arise when hydrophobic drug is formulated for oral administration. Active Pharmaceutical Ingredients (API) having deprived water solubility placed great challenges because of slow as well as reduced dissolution followed by undesirable oral bioavailability. Pharmaceutical scientists worked a lot for developing new formulation strategies to solve the hydrophobic drugs related issues reported previously. Current study is being designed to fabricate nanoparticles of Silibinin and Berberine for boosting their oral bioavailability. Nanoparticles of Silibinin and Berberine were fabricated via two different techniques (Anti-Solvent Precipitation with a Syringe Pump and Evaporative Precipitation of Nanosuspension) using nano-template engineering technology. Propylene glycol was used as stabilizer. Ethanol was used for solvent phase preparation while for anti-solvent phase, water and n-hexane containing Propylene glycol were utilized. Optimization of experimental conditions like stabilizer concentration, solvent-anti-solvent ratios and stirring speed resulted in variety of results for particle size and their related polydispersity index. Evaporative Precipitation of Nanosuspension (EPN) technique was employed for fabrication of Silibinin and Berberine nanoparticles. Silibinin and Berberine nanoparticles demonstrated particle size of 60.23 ± 2.5 nm and 71.53 ± 1.8 nm, PDI 0.217 ± 0.01 and 0.236 ± 0.01 and Zeta potential -35.49 mV and -34.17 mV. Anti Solvent Precipitation with a Syringe Pump (APSP) method was also used for the preparation of Silibinin and Berberine nanoparticles. Silibinin and Berberine nanoparticles showed particle size 104.52 ± 3.2 nm and 102.62 ± 2.8 nm, PDI 0.301 ± 0.02 and 0.284 ± 0.03 and Zeta potential -37.23 mV and -35.27 mV. XI The acquired nano formulations were characterized by using a variety of analytical techniques. The micrographs obtained through Scanning Electron Microscopy (SEM) confirmed the nanometric size particles that appeared identical and spherical in shape. These micrographs revealed the authenticity of the data obtained through Dynamic Light Scattering (DLS) analysis. Powdered X-Ray Diffractometer and Differential Scanning Calorimetry revealed the reduction in the crystallinity of the acquired nanoparticles. No drugs-excipients interaction was found in Fourier Transform Infrared Spectroscopy analysis. The obtained nanoparticles exhibited higher in vitro dissolution and solubility compared to the un-processed drugs. Nano formulations of Silibinin and berberine stored at different temperature according to International Conference on Harmonization (ICH) guidelines revealed optimum stability in the context of particle size and related polydispersity index. Nanoparticles obtained by vacuum drying were filled into the empty capsule shells accordingly. In vivo bioavailability studies revealed that nano formulations exhibit multiple folds better pharmacokinetic parameters as compared to the un-processed drug. As compared to un-processed drug, SB-APSP showed 15.56 and 6.88-folds increase in AUC0→24 and Cmax, whereas, for SB-EPN the said parameters were 18.48 and 7.14 folds increased respectively. Cmax and AUC0→24 for BB-APSP were 3.97 and 3.88 folds higher, whereas, for BB-EPN the said parameters were 4.17 and 3.89 folds greater as compared to the un-processed drug. The findings of the hepatoprotective studies revealed much better and improved results for both Silibinin and berberine in their nanoform in comparison to the un-processed form. The Liver Function Test (LFT) enzymes and Histopathological investigations depicted improved condition of liver when treated with nanoparticles compared to that of un-processed form of the same drug. The same trend for both Silibinin and berberine nanoparticles was XII observed in the anticancer studies. Primary brain tumor cells were exposed to both un processed drug and their respective nanoparticles. The nanoparticles of Silibinin and Berberine further showed comparatively improved antimicrobial, cytotoxic and antioxidant activities compared to the un-processed drug. To summarize, the fabricated nanoparticles of Silibinin and Berberine produced much better and improved results in comparison to the un-processed drug. The nano form of both drugs produced much better and significantly improved oral bioavailability along with pharmacological profile when compared to the un processed drug.
Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

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