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مولوی محبوب عالم

مولوی محبوب عالم
اس ماہ کے شذرات کا صفحہ وفات نامہ ہوا چاہتا ہے، مگر احسان فراموشی ہوگی اگر ملک کے سب سے بوڑھے صحیفۂ نگار مولوی محبوب عالم اڈیٹر پیسہ اخبار لاہور کا ماتم نہ کیا جائے، ۲۸؍ مئی کو انہوں نے اس دارِ فانی کو الوداع کہا، وہ اردو کے سب سے پہلے روزنامہ اخبار (پیسہ) کے اڈیٹر تھے، انہوں نے صرف اپنی محنت و کوشش سے سرمایہ حاصل کیا اور ملک میں تاریخ اور سیاحت ناموں کے پڑھنے کا ذوق پیدا کیا اور خود بھی یورپ اور ممالک اسلامیہ کے دوسفر کئے اور سیاحت نامے لکھے، مگر افسوس کہ اب ان کو وہ سفر پیش آیا جس کا سفرنامہ انسانوں کے ہاتھ نہیں، فرشتوں کے ہاتھ لکھتے ہیں، اس ان دیکھی منزل کے بوڑھے مسافر پر اﷲ تعالیٰ کی رحمت ہو۔
مرحوم نے ۷۴ برس کی عمر پائی۔ (سید سلیمان ندوی، جولائی ۱۹۳۳ء)
تصحیح: منشی محبوب عالم مرحوم کے تذکرہ میں یہ لکھا گیا ہے کہ وہ اردو کے پہلے روزانہ اخبار کے بانی اور اڈیٹر تھے، اس سے مراد مسلمانوں میں تھی، یعنی اردو کے پہلے اسلامی روزانہ اخبار کے وہ بانی اور اڈیٹر تھے، اردو میں منشی نولکشور لکھنو کا اودھ اخبار ان کے اخبار سے پہلے نکلا تھا اور اب تک نکل رہا ہے۔ (سید سلیمان ندوی، اگست ۱۹۳۳ء)

 

Thermostable Vaccines: Past, Present and Future Perspectives Thermostable Vaccines

Vaccines stability has a major role in the success of immunization programs and saves millions of lives every year. To stabilize vaccines cold chains are developed for storage and transport, as efficiency of vaccines is hampered if they are not kept under proper temperature. Aluminum is used for making vaccine thermostable. The development of vaccine formulation is a critical part of overall development cycle of approving, testing and producing new vaccines. However, Liquid vaccine formulation is still preferred over dry formulation because of ease in using, packaging and manufacturing. Other approaches have been used to make vaccine thermostable. This study demonstrates those processes, used to develop thermo-sensitive vaccines into thermostable vaccine and also describes vaccine formulation designing and use of heat shock protein including mHSP70 and mHSP65 to generate innate and adaptive immune response.

Development of Electrochemical Sensors for the Analysis of Drugs and Detection of Water Toxins

The current research work is intended at the designing of a various electrochemical sensors for the analysis of pharmaceutical drugs and detection of toxic heavy metal ions. Three types of electrochemical sensors were prepared and characterized. These include nanosensors, DNA biosensors and surfactant based electrochemical sensors. In the electrochemical nanosensors, TiO2 nanoparticles and COOH functionalized MWCNTs were used as receptors for the sensing of oxymetazoline drug (OMZ). The designed nanosensor helped in the sensing of OMZ with a 4.4 nM detection limit. In the second type of electrochemical sensor, DNA was used a receptor over the surface of transducer. The designed DNA biosensors were employed for the detection of a number of Schiff bases, i.e., 2-((3-chlorophenylimino)methyl)-5-(diethylamino)phenol (2-CPMP), 2-((2,4dichlorophenylimino)methyl)-5-(diethylamino)phenol (2-DPMP), 5-(diethylamino)-2((3,5-dimethylphenylimino)methyl)phenol (5-DDPMP) and 5-(diethylamino)-2-((2,6diethylphenylimino)methyl)phenol (5-DDMP). All the Schiff bases were found to interact with DNA and interestingly the oxidation signal of 5-DDMP registered 30 times increase at the fMWCNTs fabricated DNA biosensor compared to DNA biosensor alone. Moreover, surfactant based electrochemical sensors were also designed and applied for the simultaneous detection of several toxic heavy metal ions. For this purpose, 1-dodecanoyl3-(4-methoxyphenyl)-2-thiourea and 1-(3-chlorophenyl)-3-dodecanoylthiourea were used as recognition layers for the simultaneous and sensitive sensing of four and six metal ions, respectively. The electrochemical behavior of the targeted analytes at the developed sensors was probed by adsorptive stripping differential pulse voltammetry (ASDPV) and cyclic voltammetry (CV). The performance parameters of the developed sensors were evaluated from EIS, CV and ASDPV. The conditions i.e. concentration of modifiers, type of electrolyte, pH of medium deposition potential and deposition time were optimized for getting the highest current response to achieve the lowest detection limits of the targeted analytes. The modified electrodes were tested for real samples to check their validity for practical applications. The results revealed all the designed sensors to demonstrate the qualities of excellent sensitivity, selectivity and reproducibility
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