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تنقید کا یونانی اور لاطینی دور

تنقید:
تنقید عربی زبان کا لفظ ہے۔جس کے معنی جانچنا، پرکھنا ، کھرے اور کھوٹے کو الگ کرنا ہیں۔
تنقیدکی ضرورت و اہمیت:
تنقید کا سلسلہ تخلیق آدم سے شروع ہوا۔ جب اللہ تعالی نے حضرت آدم ؑ کو پید اکیا تو فرشتوں نے اللہ سے گزارش کہ کہ یہ انسان دنیا میں جاکر فساد اور لڑائی جھگڑے کرے گا۔ اس کی تخلیق کی ضرورت کیوں پیش آئی؟عبادت کے لیے تو ہم کافی ہیں۔ اس کی تخلیق پر نظر ثانی کی جائے۔اللہ نے فرشتوں کوغرض تخلیق آدم? سے آگاہ کیا۔سب سے پہلے آدمؑ پر تنقید کی گئی یعنی تخلیق پر تنقید ہوئی۔
نقاد بھی اسی دن پیدا ہوگیا تھا جس دن پہلی تخلیق ہوئی تھی۔اس حوالے سے پہلا شخص سقراط تھا۔ اس سے فلسفے کی بنیاد پڑی۔اس نے اپنے ہاتھ سے کچھ نہیں لکھا لیکن اس کی باتوں کو اس کے شاگرد افلاطون نے مکالمے کی شکل میں لکھا اور اس کتاب کا نام" مکالمات افلاطون"ہے۔اس کتاب میں زندگی کے تمام موضوعات پر بات کی گئی ہے۔ اس میں ایک مثالی ریاست کے موضوع پر بھی بات کی گئی ہے۔یوں ہم کہہ سکتے ہیں کہ تنقید کی ابتداء یونان سے ہوئی۔
بوطیقا ارسطو کی کتاب ہے۔ بوطیقا میں ارسطو نے نقل، فطرت، شاعری کی اصل، شاعری کی اقسام، المیہ کے اصول وغیرہ پر بحث کی ہے اور شاعری کا ایک آفاقی نظریہ پیش کیا ہے۔ ’’نقل‘‘ جمالیات کی ایک بنیادی اصطلاح ہے۔ ارسطو اس لفظ کا اطلاق شاعری پر کرتا ہے۔ پروفیسر بوچر کے الفاظ میں ارسطو کے ہاں نقل کا مطلب ہے حقیقی خیال کے مطابق تخلیق کرنا اور خیال کے معنی ہیں اشیا کی اصل جو عالم مثال میں موجود ہے، جس کی ناقص نقلیں اس دنیا میں نظرآتی ہیں۔ عالم حواس کی ہر شے عالم مثال کی نقل ہے۔
دنیا کا پہلا معلوم شاعر...

Protection of Working Women Rights in the Light of the Teachings of Islam

Men and women are the backbone of human civilization and both play their due roles in the society. In the present era, women are found engaged in every walk of life. Their potential was appreciated in the fields of education, research and medical since long but now they have also got prominence in the fields like army, politics, games, culture, economy, engineering and even avionics. Woman of the modern era is now a good mixture of a conscious wife, affectionate and educated mother and an active worker by increasing her importance and status through achievements in all walks of life. The main purpose of the paper was to identify the rights of women at workplace and to highlight the protection given by Islam for the rights of working women. The study was descriptive in nature. Relevant Hadiths and the examples from the lives of Sahaba regarding the justification of women to work and how their rights to be protected, was discussed. The need of the hour is to create a protected environment for women to work with dignity, without the fear of harassment and abuse which will in turn bring higher productivity and better quality of life at work.

Dihydropyrimidines As Potential Drug Candidates, Design, Synthesis, Bioevaluation and Computational Studies

Present work refers to the design, synthesis, bioevaluation and computational studies of multifunctionalized dihydropyrimidines (DHPMs) known to possess immense pharmacological activities. A series of DHPM derivatives were synthesized by different strategies. In the first strategy, one pot Biginelli reaction was carried out using three building blocks (i.e. aryl aldehydes, 1,3-dicarbonyl compounds and diamino compounds). Hence three different types of DHPMs namely 4-aryl-3,4- dihydropyrimidine-2-ones (1-44), 4-aryl-3,4-dihydropyrimidine-2-thiones (45-69) and 2-amino-1,4-DHPMs (70-79) were synthesized. Through this strategy diversity was introduced at N1, C2, C4, C5 and C6 positions of pyrimidine nucleus. Moreover, keeping in view the difficulties during the synthesis of DHPM via Biginelli three component reaction, the conditions were optimized by doing these reactions through different modes such as sonication, microwave irradiation, as well as through conventional heating. Excellent yields without any side products were obtained under mild reaction conditions under sonication using a cheap catalyst i.e. SnCl 2 . Based on a simple nucleophilic displacement scheme, another set of 2-aminopyrimidines (83-87) was also synthesized. The second strategy involved modification of different functionalities of DHPM nucleus synthesized previously through one pot strategy. This led to introduction of different diversity elements farther at C5 and C6 positions leading to pyrimidines 88-92. Besides synthesizing a variety of pyrimidines, partial synthesis of ispinesib (a well known KSP inhibitor) was carried out via two routes with a view to optimize the reaction conditions and yield of the rate limiting step each of the two synthetic strategies. Since the synthesized dihydropyrimidines are anticipated to have important pharmacological properties, therefore, all these compounds were subjected to in vitro screening for studying their potential as urease inhibitors, xanthine oxidase inhibitors, thymidine phosphorylase inhibitors, potato disc tumor inhibitors and as antiglycation agents. Compound 53 was found to have very strong potential as urease inhibitor and may serve as a lead for developing into antiulcer drug. iiiIn silico studies were also carried out on the most active compounds identified in different bioassays by doing molecular docking and pharmacophore matching. Furthermore, in silico designing of DHPM based KSP, urease and thymidine phosphorylase inhibitors was carried out with a view to develop novel KSP, urease and TP inhibitors.
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