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اسرار احمد آزاد

اسرار احمد آزاد
افسوس ہے پچھلے دنوں ہمارے ادارۂ ندوۃ المصنفین کے دو پرانے ساتھی داعیٔ اجل کولبیک کہہ کر اس دنیا سے رخصت ہوگئے۔جناب اسراراحمد آزاد اردو زبان کے ادیب اورنامور اخبار نویس تھے یوں انھوں نے غالباً کسی یونیورسٹی سے باقاعدہ کوئی سند نہیں لی تھی لیکن محض اپنی ذاتی محنت اور شوق سے اردو اورہندی کے علاوہ انگریزی میں اتنی استعداد بہم پہنچا لی تھی کہ اس زبان کے اخبارات و رسائل اورکتابیں بے تکلف پڑھ اورسمجھ لیتے تھے۔سیاسیات پران کا مطالعہ بہت وسیع تھا۔ ادارہ کے ابتدائی زمانہ میں مکتبۂ برہان کی طرف سے ان کی کتاب ’’بین الاقوامی سیاسی معلومات‘‘شایع ہوکر بڑی مقبول ہوئی تھی۔مرحوم نظر ثانی کرکے اس پر برابر اضافہ کرتے رہے چنانچہ اس کتاب کاآخری ایڈیشن جو شایع ہوا ہے وہ تین نہایت ضخیم جلدوں پرمشتمل ہے اور بے شبہ یہ کتاب اردوزبان کے پورے لٹریچر میں اپنی نوعیت کی ایک ہی ہے۔اس کے علاوہ مرحوم بہت جلد اور بہت اچھا لکھتے تھے۔ ان کی ساری زندگی جرنلزم کے نذر ہوگئی ورنہ اگر ان کو معاشی اطمینان حاصل ہوتا اورتصنیف وتالیف میں لگے رہتے تواردوزبان کے ذخیرہ میں بہت کچھ قابل قدراضافہ کرسکتے تھے۔اخلاقی اعتبار سے ان کی زندگی سراپا ایثار تھی۔خودمجرد رہے،محنت مزدوری کی اورایک بھائی کے بچوں کی تعلیم و تربیت پرہمیشہ اپنی توجہ مرکوز رکھی۔سری نگر میں روزنامہ ’’چنار‘‘ کے ایڈیٹر تھے، دھرادول میں انتقال ہوا۔اﷲ تعالیٰ مغفرت عطا فرمائے۔ [فروری۱۹۷۱ء]

 

برصغیر میں عربی ادب کا تحقیقی جائزہ اور اس کے اثرات

At the time of arrival of Muslim community in Sub-Continent Region and due to their settlement in the region Arabic Language has been prevailed and such as the system of its publication and learning has been commenced. Because the directives of Islam and laws are in the Arabic Language as per Quran & Sunna so that it is necessary to learn the Arabic language for the awareness of Islamic directions. So that to achieve the knowledge of Sharia inclu-ding the expertise the peoples of Sub-continent has been achieved the expertise of Arabic language, literature, knowl-edge Ilmul Saraf al-khawa, knowledge of al-ishtiaq & Ilmul Balaghta etc. Moreover it is clarify that Scholar of religious have shown their expertise so that the scholar of Arab have been convinced their expertise. The basic point of service in Arabic Language of Scholars of Sub-Continent that they do not served only to enhance the language but the cause of service was to serve themselves on religious matters and represents themselves on work hard and tried themselves to achieve the better performance of identification of Islam.  A positive result and effects have been achieved as a sun shining of Islam is remaining and its waves are enhancing all around the world such as the sun shining of Islam is remained in Arab world such as the publication of literature is also remaining in the Sub-Continent region in the actual shape and saved. Because the Islam will remain till the day of judg-ment and its representatives/workers will born till the date such as the scholars of literatures will also born and they will save the knowledge of Arabic.  They will alive till the Day of Judgment.

Sequencing and Analysis of a Cdna Encoding a Putative Coclaurine N-Methyltransferase Cnmt from Aristolochia Fimbriata, a Basal Angiosperm

Alkaloids are produced in plants through various pathways involving several enzymes that lead to diverse alkaloids. One of the most important alkaloid biosynthetic enzymes is coclaurine N-methyltransferase (CNMT) which is an S-adenosyl-L- methionine-dependent methyltransferase (SAM-MTase). SAM-MTases utilize S- adenosyl-L-methionine (SAM) as a cofactor to methylate other molecules. CNMT catalyzes the methylation of coclaurine. Crystal structures of more than hundred SAM-MTases have been investigated. Several O-methyltransferases have been characterized at the molecular as well as structural levels, but there have been very few molecular studies of N-methyltransferases especially about CNMTs. In this study, the amino acids sequence of Aristolochia fimbriata putative CNMT has been determined by isolating and translating the full-length cDNA. In order to investigate the mechanism of methylation by this putative CNMT, three-dimensional homology model has been built and the ligand (SAM) as well as the substrate (S- Coclaurine) has been docked into its active site. Phylogenetic analyses were performed using the MEGA 4.0 software. The phylogenetic relationship of A. fimbriata putative CNMT with their homologs has also been analyzed. In order to identify the putative CNMT gene and determine its function, online similarity searches were performed by BLAST program using the cDNA sequence as well as the putative protein that could be encoded by the gene. All the methods, applied, predicted that the gene identified might be involved in the production of CNMT. The predicted homology model consists of two domains: the N-terminal catalytic core domain and the C-terminal domain. The catalytic core domain has a central sheet of β-strands surrounded by α helices. The catalytic core domain contains binding site for VSAM. The C-terminal domain consists of alpha helices and a few beta sheets creating a pocket for the substrate in between them. The SAM-binding pocket is located next to substrate binding pocket and there is an opening in between these two cavities through which the methyl group of SAM projects towards the substrate. The most important residues involved in the methyl transfer reaction seem to be Tyr-79 and Glu-96.
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