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مولوی بشیر الدین

مولوی بشیرالدین
اسی مہینہ ہماری پرانی بزم کی ایک اہم اور قدیم یادگار مولوی بشیر الدین صاحب نے وفات پائی، وہ اپنے دور کی آخری نشانی تھے، ان کی ابتداء سرسید کی مخالفت سے ہوئی تھی، پھر ان کے حامی، مقلد اور ان کے مشن کے مبلغ بن گئے اور اپنی زندگی مسلمانوں کی تعلیمی خدمت کے لیے وقف کردی، اسلامیہ کالج اٹاوہ ان کا بڑا کارنامہ ہے۔
اخبار البشیر کے ذریعہ بھی انھوں نے بڑی خدمات انجام دیں ایک زمانہ میں وہ نہایت وقیع اخبار تھا اور اس کی آواز بڑی مؤثر تھی، تعلیم کے علاوہ بھی انھوں نے بہت سے تعمیری کام انجام دیئے، ان کی زندگی قومی کارکنوں کے لئے نمونہ تھی، وہ اگرچہ سرسید کی جماعت کے آدمی تھی، لیکن سیاسی خیالات میں آزاد اور قوم پرور تھے اور آخر تک اس مسلک پر قائم رہے۔ اب ایسے مخلص اور عملی انسان مشکل سے پیدا ہوں گے، ایک سو سال سے زیادہ کی عمر پائی، اﷲ تعالیٰ اس کہن سال خادم قوم کو اپنی رحمت و مغفرت سے سرفراز فرمائے۔ (شاہ معین الدین ندوی،جولائی ۱۹۵۶ء)

 

Patterns of Deranged Lipid Profiles in Patients of Chronic Hepatitis C Deranged lipid profile in hepatitis C patients

Liver plays an important role in lipid metabolism and any acute or chronic malfunction of the liver due to viral hepatitis or liver cirrhosis may induce lipid derangements Objective: To determine the patterns of deranged lipid profiles in patients of chronic hepatitis C Methods: It is a prospective, observational study, conducted at Medicine Department, Mayo Hospital Lahore for 6 months i.e.1stJanuary to 30th June 2018. After the ethical approval, 160 diagnosed cases of chronic hepatitis C of ages 18-70 years of either gender were selected by non-probability purposive sampling. Informed written consent was taken. Demographic information such as name, age and gender were recorded. Venous blood samples from patients after 10 to 14 hours of fasting were drawn for lipid profiles and sent to pathology laboratory. All results were expressed as mg/dl. Data were analyzed in SPSS version 22 Results: Out of 160 patients in this study, there were 94 males and 66 females. Total cholesterol was lower in 62.5% patients, normal in 33.75% patients and higher in 3.75% patients. Triglycerides levels were low in 66.25%, normal in 33.125%, and high in 0.625% patients. Low density lipoprotein (LDL) levels were low in 82.5% patients, normal in 10% and raised in 7.5% patients. High density lipoprotein (HDL) levels were low in 95%, normal in 4.375% & high in 0.625% patients Conclusions: Low levels of serum lipids including total cholesterol, triglycerides, LDL and HDL are seen in population suffering from chronic HCV infection.

Authentication of Absorbed Dose Measurements for Optimization of Radiotherapy Treatment Planning

The optimum treatment outcome of radiation therapy depends on accurate determination of radiation dose which is possible only after the detail analysis of quality assurance procedures in the Radiotherapy Treatment Planning, ensuring dosimetric characteristics of the machines and precise treatment execution. It was intended to develop dosimetric phantoms to imitate the actual patient’s anatomy for authentication of absorbed dose in target tumor and to assure the quality of radiotherapy treatment. An anthropomorphic PRESAGE ® phantom was created in the shape of a breast for external beam radiotherapy and brachytherapy. Five fields intensity modulated radiation therapy (IMRT), three field partial breast and SAVI 6-1 applicator brachytherapy plan was used to evaluate the breast phantom. The anthropomorphic breast PRESAGE ® was scanned with the Duke midsized optical CT scanner (DMOS-RPC) and optical density (OD) was converted to dose distribution. Comparisons were performed between the dose distribution calculated with the Pinnacle 3 treatment planning system, GAFCHROMIC® EBT2 film and PRESAGE ® for IMRT and 3DCRT partial breast plan. Oncentra® Master Brachy planning was also used for the comparison of PRESAGE ® and GAHCHROMIC® EBT2 film measurements. For IMRT, Gamma map comparisons showed that Pinnacle 3 well agreed with PRESAGE ® for more than 95% of comparison points of the planning tumor volume (PTV), passed ±3%/±3 mm criterion when the outer 8 mm of phantom data were excluded. Edge artifacts were observed in the optical CT reconstruction, from the surface to a depth of almost 8 mm. For 3DCRT partial breast planning Dose Volume Histograms (DVHs) of gross tumor volume (GTV), clinical tumor volume (CTV) and PTV for the PRESAGE ® dosimeter and Pinnacle 3 treatment planning system confirmed a likeness of 97.8% of the prescribed dose. Gamma map comparisons showed that all three distributions agreed with greater than 95% of comparison points passing the ±3% / ±2 mm criterion. DVHs of the skin and PTV_EVAL (PTV_ Evaluation) Brachytherapy for PRESAGE® and Oncentra® differed by a maximum of 4 to 8% respectively. A prostate anthropomorphic viRPC (Radiological Physics Center) phantom was also used which contained TLD (Thermoluminescent dosimeters) and GAFCHROMIC® EBT2 film to evaluate the spot scanning proton therapy. The results of spot scanning proton therapy shows that the Right/Left, Inferior/Superior and Posterior/Anterior aspects of the coronal/sagittal and EBT2 film measurements were within ±7%/±4mm of the treatment planning system (TPS). This work demonstrates the feasibility of the PRESAGE ® to be fashioned into anthropomorphic shape and establishes the accuracy of Pinnacle 3 for breast IMRT as well as for 3D and brachytherapy planning. Furthermore, the extension of this work can lead to investigate 3D dosimetry with more complex anthropomorphic phantoms. RPC-Anthropomorphic prostate phantom could be used to establish quality assurance of spot scanning proton beam within certain confidence levels. The quality of treatment can be improved with the utilization of PRESAGE® in both external beam radiotherapy as well as brachytherapy. An anthropomorphic phantom is a good substitute of actual patients’ and can be a valuable tool for treatment planning in all types of radiation therapy including spot scanning proton therapy for authentication of absorbed dose measurements and resultantly can increase the accuracy and quality of the treatment.
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