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عارف خان
عارف خان
پاکستان پیپلز پارٹی کے سنیئر رہنما اور قید وبند کی صعوبتیں برداشت کر نے والا ،شاہی قلعہ کا قید ی ،ہر تحریک میں بڑھ چڑھ کر حصہ لینے والا عارف خا ن کی 64ویں سالگرہ کی تقریب سبزہ زار میں ہوئی ۔
اسلامی ریاست میں غیر مسلم رعایا کے حقوق
“Minority” is a word which is considered a challenge for any political system. This article discusses how a certain political system deals with the idea and rights of a minority. If a minority enjoys the privileges in a society that political system is considered as perfect. Islam, the revealed religion, has not overlooked the status of a minority. Rights of a minority is one of the top priorities in Islam. This article brings to the fore the very status which Islam gives to the minorities and which they enjoyed while living in the Islamic poltical and social set up. Islam not only gives minorities the right to live in an Islamic Society, but also gives them protection. The word “Dhimmis” gives minorities the protection in an Islamic society which they never entertain in their own society. Whether it was the time of the Holy Prophet, the Abbasid’s or Umayyad, everywhere in the Islamic society they enjoyed not only as minorities but also they were allowed to build churches, join Islamic forces and to become viziers, etc. It clearly reveals that Islam is a religion of peace that not only gives good tidings to the believers but aslo to the minorities who live among them. This article is a small replica of what the minorities enjoyed in the Islamic society.Synthesis and Characterization of Heteroleptic Copper Complexes: As Prospective Antimicrobial, Cytotoxic and Antioxidative Agents
Copper(I) halide complexes with N,Nʹ-disubstituted thioureas and triphenylphosphine have been synthesized by the reaction of halotris(triphenylphosphine)copper(I) and respective thioureas (121) at 60 °C. The newly synthesized complexes were fully characterized by various instrumental techniques like FT-IR, multinuclear (1H, 13C, 19F, 31P) NMR spectroscopy while elemental analyses were carried out using a CHNS analyzer and atomic absorption spectroscopy. Some of the copper(I)-N,Nʹ-disubstituted thiourea complexes (A3, A7, A9, A16, B1, B3, B4, B6, B13, B14, B18, B19, C1, C3, C8, C9, C10, C12, C14, and C15) were analyzed via single crystal XRD for structural elucidation. From single crystal XRD it has been identified that copper(I) adopted distorted tetrahedral geometry in coordination with sulphur (substituted thiourea), two phosphorus (triphenylphosphine) and halogen. Most of the complexes were stabilized by intramolecular hydrogen bonding. The synthesized complexes were screened for cytotoxicity (Brine shrimp), antibacterial, antifungal, antileishmanial, antioxidant and DNA binding studies. In Brine shrimp lethality assay complexes B17 and B11 were the most active with LC50 of 19.6 µg mL–1 and 20.1 µg mL–1, respectively. In case of antibacterial activities, in the chlorinated series (A), the most active complex against E. Aerogens was A15, against B. Bronchiseptaca it was A12 and against S. Typhimurium were A9 and A3 with ZOI value comparable to that of the reference commercial drug. Similarly, in the iodinated series (C), the most active complex against B. Bronchiseptaca was C13 and against S. Typhimurium it was C9 with ZOI values of 20±1.46 and 19±1.27 mm, respectively. Against A. fumagatus(Fungi) the most active complex was B14 with a ZOI value of 19.5±1.46 mm which was comparable to that of the reference value. In Leishmanicidal activity all the test samples were active against L. tropica with LC50 values in the range of 20 to 50 µg mL–1. In the assay of DPPH Free-Radical Scavenging, all the test samples were significantly active toward DPPH and the antioxidant activity of the complexes was found within the range of 54.96-62.67%. From UV-vis spectroscopy and molecular docking studies it has also been observed that copper(I) tetrahedral complexes interact strongly with the DNA via a groove binding mode. From molecular docking the highest value of Kb was found to be 1.08×105 for A12 which is attributed to the intra-strand cross linking of benzo[d]thiazol-2-yl of thiourea in the complex with DA17 and DT6 base pairs of DNA in addition to groove binding interactions.Journals by Discipline
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