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مناقب

مناقب

ٹُر گئے کر کے مندڑا حال
وسدے ہاسے سجناں نال
سجناں باہجھوں دل کرلاندا
رو رو ہاڑے ترلے پاندا
ماہی جلدی مکھ وکھال
ٹُر گئے کر کے مندڑا حال

تحدت للعالم الإسلامي ودور الشباب في مواجهتها

Youth are the real asset of a nation, nation make progress by channelizing, the energy and effects of youth in the right direction. If youth of a nation go astray, the nation will be bound to fail. This short paper intends to look at the challenges faced by our youth for example, the political, religious and philosophical influence of anti-Islam powers, the use of all resources to attract youth to Islam, the attraction of Muslim youth to philosophy, to look into the influence of west through education which is leading the nation to financial and social way wardenss Indecency, Arabic language is replaced with other language for teaching and understanding of the Qur’ān and Unemployment, poverty and a sense of uselessness of youth is a huge challenge. This factor is leading the youth to stealing, robbery and other moral weaknesses. This short article will try to throw light on the challenges and responsibilities of youth. The history of mankind tells us that it is only the young people, who took the revolutionary measures to change the societies. Youth is the prime time of ones life. It is the time when all energies are at their peak. So one should get advantage of youth before getting old and helth before falling sick. As they say “new broom sweap clean”. Young people can bring great changes in cleaning socieities from evils. Muslim youth has great resficial to whole humanity. Today, youth is facing many challenges in their life. These challenges are in social, moral, educational, intellectual and political fields. To cope with them youth must have the knowledge and awareness. This short article tends to throw light on these challenges and gives ways and remedies to face them successfully.

Anticarcinogenic Activity of Terpeniod Containing Plants Against Induced Hepatocellular Carcinoma Hcc

Hepatocellular Carcinoma is 6th most predominantly existing cancer and second largest contributor to human mortality all over the world. This study is focused on identification of ―Potent Anticancer terpenes‖ from selected experimental plants that may be successfully practicized in cancer chemotherapeutic mainstream. Twenty five plants were taken under consideration for present piece of work. Ethanolic extracts of different parts of these plants were prepared. Standard analytical methods including UV-VIS Spectroscopy, FTIR and GCMS effectively confirmed presence of a large number of secondary metabolites i.e. Flavonoids, Phenols, Terpenoids, Quinine, Saponins and Alkaloids in these extracts. Quenching potential of ethanolic extracts against DPPH free radical fabricated possible antioxidant dynamics of selected experimental plants. During present work we focused on the role of identified plant ―Terpenoids‖ involved in Hepatocurative as well as Hepatoprotective activities. The ethanolic extracts and these identified effective anticancer ―terpenes‖ were used for further experimentation on Hepatocellular Carcinoma in O. cuniculus. In vitro cytotoxic effects of ethanolic extracts of experimental plants and identified ―terpenes‖ (Hexadecanoic acid, methyl ester, Methyl decanoate, n- Hexadecanoic acid ) were assessed by MTT (3-[4, 5-dimethylthiazole-2-yl]-2, 5-diphenyl-tetrazolium bromide) assay against Mouse Fibroblasts (3T3) cell lines along with their IC50 calculation. Hepatocellular Carcinoma was induced by CCl4 administration in O. cuniculus. The safe doses of CCl4, ethanolic extracts and identified ―terpenes‖ were also optimized during this piece of work. Hepatocurative and Hepatoprotective potentials of plants extracts and their identified ―terpenes‖ along with standard drugs (in medical use for treatment of Hepatocellular Carcinoma) were effectively analysed by monitoring physiological changes (pH of saliva, temperature, blood glucose, body weight) in induced Hepatic Carcinomic O. cuniculus. Furthermore, Hematological investigations (Hb, RBC, TLC, MCV, MCH, MCHC and Platelets), changes in Liver Biochemical Enzymes (Alkaline phosphatase, Aspartate amino Transferase and Alanine aminotransferase) and Hepatic Carcinoma Marker (Alpha Fetoprotein) efficiently marked Therapeutic as well as Prophylactic outcomes followed by Histo-Pathological studies of Carcinomic and healthy livers following Hematoxylin and Eosin Staining. xxiii The research work was aimed to critically examine potential role of naturally occurring ―Terpenoids‖ from diverse botanical origins for chemoprevention as well as chemotherapy of liver tumors. Both in vitro and in vivo effects were noted and recorded. We successfully identified the anticancer ―terpenes‖ giving better and non-toxic results against Hepatocellular Carcinoma in comparison to synthetic anti-cancerous drugs in market. In addition to this, we also recorded similar anticancerous response of ethanolic extracts of selected experimental plants against induced Hepatocellular Carcinoma in O. cuniculus. The results of the present piece of work are promising and may be very helpful for finding green, cost effective and eco-friendly chemopreventive and chemotherapeutic measures to deal successfully with liver carcinomas.
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