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صدیق رضی اللہ تعالیٰ عنہ کے لیے ہے خدا کا رسول صلی اللہ علیہ و آلہٖ وسلم

’’صدیق کے لئے ہے خدا کا رسول بس‘‘
امت کے بہترین افراد کو نبیصلی اللہ علیہ و آلہٖ وسلم کے صحابہ رضوان اللہ تعالیٰ اجمعین کے نام سے یاد کیا جا تا ہے ، یہ ایسے نفوس قدسیہ ہیں جن کے پیشِ نظر نزول وحی ہوتا ہے۔ جن کی نظر یں جلوۂ نبوت کا طواف کرتی ہیں۔ جن کے کانوں سے زبانِ مصطفیٰ صلی اللہ علیہ و آلہٖ وسلمسے نکلنے والے الفاظ معانقہ کرتے ہیں، جن کی کفِ پانقش نعلینِ مصطفی صلی اللہ علیہ و آلہٖ وسلمکی تلاش میں سر گرداں رہتی ہیں، جن کے شب وروز معجزات نبی صلی اللہ علیہ و آلہٖ وسلم کا مشاہدہ کرتے رہتے ہیں، نبی صلی اللہ علیہ و آلہٖ وسلمکی نظر یں جن کی تربیّت کرتی ہیں، جن کی آنکھوں میں نبوت سراپا، قلوب و اذہان میں نبی صلی اللہ علیہ و آلہٖ وسلمکی سوچ اور تعمیر میں نبی صلی اللہ علیہ و آلہٖ وسلم کا کردار پیش نظر ہوتا ہے۔
جس طرح جملہ انبیاء کرام علیہ السلام میں گنبدِخضریٰ کے مکین کا کوئی ثانی نہیں ہے۔ اسی طرح آپ صلی اللہ علیہ و آلہٖ وسلم کے صحابہ رضوان اللہ تعالیٰ اجمعین کی بھی مثال دیگر انبیاء علیہ السلام کے صحابہ سے نہیں ملتی۔ حضور صلی اللہ علیہ و آلہٖ وسلم کے تمام صحابہ کرام رضوان اللہ تعالیٰ اجمعین آپ صلی اللہ علیہ و آلہٖ وسلم کے جانثار تھے لیکن جانثاری کی جو مثالیں صدیقِ اکبر ثنے قائم کیں۔ تاریخ کے اوراق ایسی مثال سے قاصر ہیں۔ تاریخِ اسلام کا مؤرخ ایسی مثال پیش کرنے سے قاصر ہے، تاریخِ عالم رقم کرنے والے جملہ مؤرخین ایک عظیم محبت اور جانثاری کی مثال دینے کیلئے اپنے لبوں کو اور اپنے قلم کوجنبش دینے میں بے بس نظر آتے ہیں۔ سیدنا صدیقِ اکبر ص کا اوڑھنا بچھونا سنت ِمصطفی صلی اللہ علیہ...

سائیں رفیق رانجھا تے بابا جی قصور مند

This article covers the poetic and research services of Sufi poet Sain Muhammad Rafique Ranjha from Hamza Ghous Sialkot. He is a Punjabi "Sofi "poet and a compiler. In this article, I have already mentioned his own poetry collection and life. In his own book, he has used a dozen genres of poetry. This Sufi poet, who is experimenting with new and old genres, but “Rubai” is his favorite genre. The first book "Warasat-e- Faqr" by Sain Muhammad Rafique Ranja consists of 418 pages which has been composed. While the second book “Suchay Moti” is by the famous Punjabi poet of Gujarat Baba Ji Qasoor Mand which has 290 pages. It is published in 2017. Both books contain mystical poetry. Along with the books, brief information about the lives of the authors is also given.

Genetic Variants in the Leptin, Leptin Receptor and Fto Genes in Obese Pakistani Population

Obesity is a global public health problem of 21 st century. Recent surveys show that the incidence of obesity has reached epidemic proportions in the world and its rate is increasing both in children and adults. It is a multi-factorial and heterogeneous condition due to complex interaction between genetic, behavioral and environmental factors. Recent reports suggest that the genetic factors play an important role in the development of obesity. A number of genetic variants in different genes have been reported to be associated with obesity in various populations. The current study was carried out to gain an insight into the role of fat mass and obesity associated gene (FTO), leptin receptor (LEPR) and leptin (LEP) gene variants in the pathophysiology of obesity in local population. A total of 394 subjects (obese=239, BMI ≥30Kg/m 2 or 95 th percentile and non-obese=155, BMI<25Kg/m 2 or 5 th -85 th percentile) between 5-45yrs of age were analyzed for Q223R, G2548A and rs9939609 variants of LEPR, LEP and FTO genes respectively, and their association with anthropometric and metabolic parameters was determined. Body weight, height, waist and hip circumference and blood pressure (BP) were measured, BMI and Waist Hip Ratio (WHR) were determined. Fasting blood glucose (FBG), insulin, leptin and leptin receptors were measured in duplicate using ELISA and HOMA-IR was calculated. DNA was extracted from the whole blood; genotyping of the polymorphisms were carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Data were analyzed using SPSS version 17; parameters were compared using t-test, one way ANOVA, Tukey post hoc test, Pearson test, Chi-square test, general linear model (GLM) multivariate analysis and Hardy Weinberg equilibrium test. In the present study LEP G2548A polymorphism was found to be associated with obesity in female children and adolescents (≤18years of age). Female children and adolescents carrying G allele of G2548A polymorphism were found to have 2.23 times increased risk of obesity in (95% CI=1.07–4.63). G allele of G2548A polymorphism was found to be associated with increased body weight, height, BMI, hip circumference, WHR, HOMA-IR, plasma insulin and leptin levels. No significant difference was found in genotype and allele frequencies of LEPR Q223R polymorphism between obese and non obese subjects. No association of LEPR Q223R polymorphism was observed with any of the anthropometric and metabolic traits related to obesity. FTO rs9939609 variant was found to be associated with obesity in adult females (>18years of age). Women carrying A allele of this polymorphism were found to have 2.81 times increased risk of obesity (95% CI=1.31-6.04). A allele was found to be xiiiassociated with increase in body weight, BMI, waist and hip circumference, WHR, BP, FBG, HOMA-IR, plasma insulin and leptin levels and decrease in leptin receptor levels. LEP (G2548A) variant is an important predictor for increased plasma leptin and BMI among female children and adolescents. FTO (rs9939609) variant is associated with BMI and risk of obesity in adult females, carrier of A allele had higher FBG, HOMA-IR and leptin levels independent of BMI.
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